Zeno - Clearly Outsmarts Pimples
Heat Shock Response
ClearPoint™ technology is the key to Tyrell's ability to provide heat therapy for the successful treatment of skin lesions. Tyrell's proprietary ClearPoint technology delivers a precisely controlled heat dose for a specific period of time to a pimple. This heat triggers a cascade of events that include the induction of heat shock protein responses and the subsequent killing of the bacteria. This effectively reduces the inflammatory response and allows the skin to return to a healthy state more quickly.
ClearPoint technology triggers a heat shock response in micro-organisms that cause skin lesions, bringing about the self-destruction of those micro-organisms and allowing the skin to return to a healthy, normal state. In the case of acne, the P. acnes bacterium is the root cause of 90% of all acne pimples. Zeno is a simple electronic consumer product designed to safely heat an acne lesion to a pre-set temperature range known to generate heat shock response. Heat shock response is a reaction bacteria have to heat whereby they transcript a number of genes and activate heat-shock proteins. These heat-shock proteins participate in the bacteria's death by causing the bacteria to self-destruct. Fortunately, the level of heat required is not sufficient to cause damage to the skin. Zeno is more effective on active acne lesions than any current OTC or prescription treatment with none of the potential side effects. Additionally, this all-natural solution to acne treatment offers effectiveness on most acne within a mater of days rather than weeks, a common problem with OTC and prescription treatments.
Acne lesion reduces in days with Zeno vs. weeks with other available treatment. CAUTION: This chart compares data from differing tests with widely varying protocols, hence data points are not directly comparable. This is only intended to be a general comparison.
Sources: Shalita, Harth, and Elman 3; Paithanker et al. Tyrell Clinical Trial
With Tyrell's ClearPoint acne heat treatment technology, P. acnes is destroyed by a process called heat shock response. Heat shock response is a reaction bacteria have to heat whereby they transcript a number of their genes and activate heat-shock proteins. These heat-shock proteins participate in the bacteria's death by causing the bacteria to self-destruct. P. acnes self-destructs in the acne lesion preventing infection and allowing the skin to return to a healthy state. Fortunately, the level of heat required is not sufficient to cause damage to the skin.
Tyrell performed numerous lab studies on P. acnes to assess the temperature range in which heat shock response occurs in this bacteria, including a waterbath and a thermal cycler study, known for accuracy to tenths of a degree. DNAtrix, Inc., a molecular pharmaceutical company jointly owned by Dr. Conrad and the Board of Regents of the University of Texas , performed the thermal cycler testing which was critical in determining if P. acnes ' heat shock response occurs below the point of heat damage of human skin. Futhermore, these tests were critical in assessing the rate of P. acnes death at various temperatures over time (temperature versus time). The results indicated significant death of P. acnes at a temperature well below the thermic damage of human skin.
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